Birth defects research. Part A, Clinical and molecular teratology · 2010
Decongestant use during pregnancy and its association with preterm delivery.
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Hernandez Rohini K, Mitchell Allen A, Werler Martha M
Аннотация
BACKGROUND: Despite the frequent intake of decongestants during pregnancy, only one study to date has evaluated the association of decongestants with preterm delivery, and it identified a reduced risk. We examined this association in more detail.
METHODS: Using a population-based random sample of 3271 Massachusetts live-born births without major malformations, we categorized decongestant exposure according to timing, frequency of use, route, and indication. Preterm birth was defined as a gestational age of <37 completed weeks. We estimated hazard ratios and examined confounding by indication by examining various strata of women and through multivariate adjustment.
RESULTS: Compared to nonexposed women, those who took decongestants during the second or third trimester only were less likely to experience preterm delivery (HR, 0.42; 95% CI, 0.21-0.84). This association was observed only for women without preeclampsia.
CONCLUSIONS: A protective association between decongestant use and preterm delivery has now been observed in two studies; however, the possibility of confounding by underlying condition remains.
METHODS: Using a population-based random sample of 3271 Massachusetts live-born births without major malformations, we categorized decongestant exposure according to timing, frequency of use, route, and indication. Preterm birth was defined as a gestational age of <37 completed weeks. We estimated hazard ratios and examined confounding by indication by examining various strata of women and through multivariate adjustment.
RESULTS: Compared to nonexposed women, those who took decongestants during the second or third trimester only were less likely to experience preterm delivery (HR, 0.42; 95% CI, 0.21-0.84). This association was observed only for women without preeclampsia.
CONCLUSIONS: A protective association between decongestant use and preterm delivery has now been observed in two studies; however, the possibility of confounding by underlying condition remains.
Предметные рубрики MeSH
Cohort StudiesConfounding Factors, EpidemiologicDelivery, ObstetricFemaleGestational AgeHumansMassachusettsNasal DecongestantsObstetric Labor, PrematureParturitionPhenylpropanolaminePregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondPregnancy Trimester, ThirdPseudoephedrineRetrospective StudiesRhinitisRisk FactorsSurveys and Questionnaires