Progression of squamous carcinoma in situ of the vulva to invasive carcinoma after systemic bleomycin therapy.

Progression of squamous carcinoma in situ of the vulva to invasive carcinoma, in the same area, after systemic Bleomycin therapy, is described. Such progression is an exception and not the rule in the natural history of this disease. Conservative therapy should be used, especially in young women.