International urology and nephrology · 2016
Prognostic value of Ki67 and p63 expressions in bladder cancer patients who underwent radical cystectomy.
СтатьяНазвание и аннотация: Перевод в очереди
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Wang Lujia, Zhou Minwei, Feng Chenchen, Gao Peng, Ding Guanxiong, Zhou Zhongwen, Jiang Haowen, Wu Zhong, Ding Qiang
Аннотация
INTRODUCTION: Radical cystectomy (RC) is the gold standard treatment for patients with high-risk non-muscle-invasive bladder cancer and muscle-invasive bladder cancer (MIBC) . However, despite aggressive treatment, mortality rates of patients are still high. Therefore, it is crucial to indentify some practical prognostic factors for cancer-specific survival in those patients to guide our therapeutic strategies.
MATERIALS AND METHODS: We included 103 patients treated with RC for urothelial bladder cancer (UBC) between July 2007 and June 2014 in our institution and analyzed their clinicopathological parameters. The mean follow-up was 22 months (range 2-89 months).
RESULTS: Advanced tumor T stage, N stage, ABO blood type, a history of DM and positive p63 expression were independent factors for worse survival in all patients who underwent RC. Moreover, in female gender, high Ki67 expression was significant risk factor for cancer-specific survival (CSS) in MIBC patients.
CONCLUSION: Our study demonstrated that immunohistochemical expressions of Ki67 and p63 are potential prognostic factors for UBC patients who underwent RC.
MATERIALS AND METHODS: We included 103 patients treated with RC for urothelial bladder cancer (UBC) between July 2007 and June 2014 in our institution and analyzed their clinicopathological parameters. The mean follow-up was 22 months (range 2-89 months).
RESULTS: Advanced tumor T stage, N stage, ABO blood type, a history of DM and positive p63 expression were independent factors for worse survival in all patients who underwent RC. Moreover, in female gender, high Ki67 expression was significant risk factor for cancer-specific survival (CSS) in MIBC patients.
CONCLUSION: Our study demonstrated that immunohistochemical expressions of Ki67 and p63 are potential prognostic factors for UBC patients who underwent RC.
Предметные рубрики MeSH
AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Transitional CellCystectomyFemaleFollow-Up StudiesHumansImmunohistochemistryKi-67 AntigenMaleMembrane ProteinsMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisRetrospective StudiesTime FactorsTreatment OutcomeUrinary BladderUrinary Bladder Neoplasms