Ophthalmic plastic and reconstructive surgery · 2025
Diagnostic Role of Tissue Biopsy in Leukemic or Lymphomatous Infiltrative Optic Neuropathy: A Case Report and Systematic Review of Literature.
СтатьяСистематический обзорКлинический случайНазвание и аннотация: Перевод в очереди
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Younis Abdullah, Shiwani Haaris, Green Elspeth K Y, Foo Edward, Sharma Vinod, Dignan Fiona L, Dharmasena Aruna
Аннотация
PURPOSE: The authors aimed to explore the role of tissue biopsy in diagnosing leukemic or lymphomatous infiltrative optic neuropathy through a systematic literature review and presentation of a new case.
METHODS: A systematic literature review was conducted using PubMed, Scopus, and Google Scholar databases to identify cases of leukemic or lymphomatous optic neuropathy in which optic nerve or sheath biopsy was performed. A newly reported case was also included.
RESULTS: A total of 420 studies were identified, with 26 meeting inclusion criteria. In total 29 patients were included, with a mean age of 55.9 years. Of these, 48.3% had a known history of leukemia or lymphoma, and 50% were in remission at presentation. Imaging showed optic nerve enhancement and enlargement in most cases. Biopsies were performed on the optic nerve, sheath, chiasm, tract, or surrounding orbital tissue. Direct nervous tissue biopsies (optic nerve, chiasm, or tract) were diagnostic in 100% of cases, while only 18.2% of sheath biopsies were diagnostic. Visual outcomes were poor, with many presenting with no light perception. Postoperatively, vision remained stable in 40%, deteriorated in 20.7%, and improved in 17.2%.
CONCLUSIONS: Tissue biopsy remains a critical last-line investigation for diagnosing leukemic or lymphomatous optic neuropathy when noninvasive methods remain inconclusive. While highly diagnostic, optic nerve biopsy carries visual risk, especially for patients with residual vision. Direct nerve biopsy is recommended for severe vision loss, while a more cautious surgical approach, considering alternative diagnostic techniques, is advised for those with partially preserved vision. Optic nerve sheath biopsy, though theoretically safer, has a limited diagnostic yield.
METHODS: A systematic literature review was conducted using PubMed, Scopus, and Google Scholar databases to identify cases of leukemic or lymphomatous optic neuropathy in which optic nerve or sheath biopsy was performed. A newly reported case was also included.
RESULTS: A total of 420 studies were identified, with 26 meeting inclusion criteria. In total 29 patients were included, with a mean age of 55.9 years. Of these, 48.3% had a known history of leukemia or lymphoma, and 50% were in remission at presentation. Imaging showed optic nerve enhancement and enlargement in most cases. Biopsies were performed on the optic nerve, sheath, chiasm, tract, or surrounding orbital tissue. Direct nervous tissue biopsies (optic nerve, chiasm, or tract) were diagnostic in 100% of cases, while only 18.2% of sheath biopsies were diagnostic. Visual outcomes were poor, with many presenting with no light perception. Postoperatively, vision remained stable in 40%, deteriorated in 20.7%, and improved in 17.2%.
CONCLUSIONS: Tissue biopsy remains a critical last-line investigation for diagnosing leukemic or lymphomatous optic neuropathy when noninvasive methods remain inconclusive. While highly diagnostic, optic nerve biopsy carries visual risk, especially for patients with residual vision. Direct nerve biopsy is recommended for severe vision loss, while a more cautious surgical approach, considering alternative diagnostic techniques, is advised for those with partially preserved vision. Optic nerve sheath biopsy, though theoretically safer, has a limited diagnostic yield.