European journal of haematology · 2015
Smoking and philadelphia-negative chronic myeloproliferative neoplasms.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lindholm Sørensen Anders, Hasselbalch Hans Carl
Аннотация
OBJECTIVE: A single-institution case-control study was conducted to test the hypothesis that a history of smoking was associated with a higher risk of developing MPNs compared to CLL.
METHODS: Cases (n = 323) were all MPN patients diagnosed in a 10-year period, and controls (n = 333) were all patients with CLL diagnosed during that same period. Odds ratios and 95% confidence intervals were calculated and adjusted for gender and age by logistic regression.
RESULTS: A significant association between a personal history of smoking and the risk of MPNs compared to CLL were observed for all MPNs (OR = 1.73, 95%CI 1.25-2.40) and for the WHO 2008 classified MPNs (OR = 1.64, 95%CI 1.16-2.30).
CONCLUSIONS: No other larger case-control study has described a positive association between the risk of MPN and a history of smoking in the general MPN population. This association might be explained by the chronic inflammatory state and oxidative stress in response to smoking, eliciting genomic instability in the stem cell compartment and ultimately clonal evolution resulting in MPNs.
METHODS: Cases (n = 323) were all MPN patients diagnosed in a 10-year period, and controls (n = 333) were all patients with CLL diagnosed during that same period. Odds ratios and 95% confidence intervals were calculated and adjusted for gender and age by logistic regression.
RESULTS: A significant association between a personal history of smoking and the risk of MPNs compared to CLL were observed for all MPNs (OR = 1.73, 95%CI 1.25-2.40) and for the WHO 2008 classified MPNs (OR = 1.64, 95%CI 1.16-2.30).
CONCLUSIONS: No other larger case-control study has described a positive association between the risk of MPN and a history of smoking in the general MPN population. This association might be explained by the chronic inflammatory state and oxidative stress in response to smoking, eliciting genomic instability in the stem cell compartment and ultimately clonal evolution resulting in MPNs.