Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project.
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Morton Lindsay M, Sampson Joshua N, Cerhan James R, Turner Jennifer J, Vajdic Claire M, Wang Sophia S, Smedby Karin E, de Sanjosé Silvia, Monnereau Alain, Benavente Yolanda, Bracci Paige M, Chiu Brian C H, Skibola Christine F, Zhang Yawei, Mbulaiteye Sam M, Spriggs Michael, Robinson Dennis, Norman Aaron D, Kane Eleanor V, Spinelli John J, Kelly Jennifer L, La Vecchia Carlo, Dal Maso Luigino, Maynadié Marc, Kadin Marshall E, Cocco Pierluigi, Costantini Adele Seniori, Clarke Christina A, Roman Eve, Miligi Lucia, Colt Joanne S, Berndt Sonja I, Mannetje Andrea, de Roos Anneclaire J, Kricker Anne, Nieters Alexandra, Franceschi Silvia, Melbye Mads, Boffetta Paolo, Clavel Jacqueline, Linet Martha S, Weisenburger Dennis D, Slager Susan L
Аннотация
METHODS: We pooled individual-level data from 20 case-control studies (17471 NHL cases, 23096 controls) from North America, Europe, and Australia. Centralized data harmonization and analysis ensured standardized definitions and approaches, with rigorous quality control.
RESULTS: The pooled study population included 11 specified NHL subtypes with more than 100 cases: diffuse large B-cell lymphoma (N = 4667), follicular lymphoma (N = 3530), chronic lymphocytic leukemia/small lymphocytic lymphoma (N = 2440), marginal zone lymphoma (N = 1052), peripheral T-cell lymphoma (N = 584), mantle cell lymphoma (N = 557), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (N = 374), mycosis fungoides/Sézary syndrome (N = 324), Burkitt/Burkitt-like lymphoma/leukemia (N = 295), hairy cell leukemia (N = 154), and acute lymphoblastic leukemia/lymphoma (N = 152). Associations with medical history, family history, lifestyle factors, and occupation for each of these 11 subtypes are presented in separate articles in this issue, with a final article quantitatively comparing risk factor patterns among subtypes.
CONCLUSIONS: The International Lymphoma Epidemiology Consortium NHL Subtypes Project provides the largest and most comprehensive investigation of potential risk factors for a broad range of common and rare NHL subtypes to date. The analyses contribute to our understanding of the multifactorial nature of NHL subtype etiologies, motivate hypothesis-driven prospective investigations, provide clues for prevention, and exemplify the benefits of international consortial collaboration in cancer epidemiology.