Transplantation · 2003
Simultaneous kidney-pancreas transplantation in a patient with small lymphocytic lymphoma.
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Romero A L Ramon, Reddy K Sudhakar, Johnston Thomas D, Waid Thomas W, Wade MeKeown J, Khan Taqi, Karounos Dennis, Doukas Michael, Samayoa Luis, Ranjan Dinesh
Аннотация
BACKGROUND: Experience with organ transplantation in patients with indolent lymphoma is limited, and it is unknown how the natural history of the disease is altered by chronic immunosuppressive therapy.
METHODS: A patient with type 1 diabetes and renal failure who underwent simultaneous kidney-pancreas transplantation was found to have stage IV small lymphocytic lymphoma at the time of transplantation. He received quadruple immunosuppressive therapy using interleukin (IL)-2 receptor antibody, tacrolimus, mycophenolate mofetil, and prednisone.
RESULTS: Patient is doing well 3 years posttransplant with excellent graft function of both the kidney and pancreas without any evidence of progression of the disease.
CONCLUSION: Indolent lymphoma should not be considered an absolute contraindication to organ transplantation.
METHODS: A patient with type 1 diabetes and renal failure who underwent simultaneous kidney-pancreas transplantation was found to have stage IV small lymphocytic lymphoma at the time of transplantation. He received quadruple immunosuppressive therapy using interleukin (IL)-2 receptor antibody, tacrolimus, mycophenolate mofetil, and prednisone.
RESULTS: Patient is doing well 3 years posttransplant with excellent graft function of both the kidney and pancreas without any evidence of progression of the disease.
CONCLUSION: Indolent lymphoma should not be considered an absolute contraindication to organ transplantation.