Intravenous immune globulin therapy for antibody immunodeficiency.

High doses of intravenous immune globulin produced meaningful clinical responses in three patients with altered immune function. One patient had a history of repeated infection with gram-positive pneumococci, another patient had second-degree burns and previously undiagnosed chronic leukemia of unknown etiology, and the third patient had frequent infections of the intestinal tract with symptoms of malabsorption and gluten intolerance. All three of the cases are examples of antibody immunodeficiency. After receiving intravenous immune globulin, all three patients experienced complete remission of infection.