Current drug research reviews · 2021
SeDeM Expert System, an Innovative Tool for Developing Directly Compressible Tablets: A Review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Singh Inderbir, Thakur Ajay Kumar, Bala Rajni, Madan Reecha
Аннотация
BACKGROUND: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters derived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameters derived diagram that can be used as a research tool for reducing the product development time. The best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability.
OBJECTIVE: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained-release formulations, and development of tablets of taste-masked drugs.
CONCLUSION: In the present review paper, the development and applications of SeDeM and SeDeMODT systems have been discussed in detail.
OBJECTIVE: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained-release formulations, and development of tablets of taste-masked drugs.
CONCLUSION: In the present review paper, the development and applications of SeDeM and SeDeMODT systems have been discussed in detail.