Nature · 2020

Identification of type 2 diabetes loci in 433,540 East Asian individuals.

СтатьяМетаанализПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди

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Spracklen Cassandra N, Horikoshi Momoko, Kim Young Jin, Lin Kuang, Bragg Fiona, Moon Sanghoon, Suzuki Ken, Tam Claudia H T, Tabara Yasuharu, Kwak Soo-Heon, Takeuchi Fumihiko, Long Jirong, Lim Victor J Y, Chai Jin-Fang, Chen Chien-Hsiun, Nakatochi Masahiro, Yao Jie, Choi Hyeok Sun, Iyengar Apoorva K, Perrin Hannah J, Brotman Sarah M, van de Bunt Martijn, Gloyn Anna L, Below Jennifer E, Boehnke Michael, Bowden Donald W, Chambers John C, Mahajan Anubha, McCarthy Mark I, Ng Maggie C Y, Petty Lauren E, Zhang Weihua, Morris Andrew P, Adair Linda S, Akiyama Masato, Bian Zheng, Chan Juliana C N, Chang Li-Ching, Chee Miao-Li, Chen Yii-Der Ida, Chen Yuan-Tsong, Chen Zhengming, Chuang Lee-Ming, Du Shufa, Gordon-Larsen Penny, Gross Myron, Guo Xiuqing, Guo Yu, Han Sohee, Howard Annie-Green, Huang Wei, Hung Yi-Jen, Hwang Mi Yeong, Hwu Chii-Min, Ichihara Sahoko, Isono Masato, Jang Hye-Mi, Jiang Guozhi, Jonas Jost B, Kamatani Yoichiro, Katsuya Tomohiro, Kawaguchi Takahisa, Khor Chiea-Chuen, Kohara Katsuhiko, Lee Myung-Shik, Lee Nanette R, Li Liming, Liu Jianjun, Luk Andrea O, Lv Jun, Okada Yukinori, Pereira Mark A, Sabanayagam Charumathi, Shi Jinxiu, Shin Dong Mun, So Wing Yee, Takahashi Atsushi, Tomlinson Brian, Tsai Fuu-Jen, van Dam Rob M, Xiang Yong-Bing, Yamamoto Ken, Yamauchi Toshimasa, Yoon Kyungheon, Yu Canqing, Yuan Jian-Min, Zhang Liang, Zheng Wei, Igase Michiya, Cho Yoon Shin, Rotter Jerome I, Wang Ya-Xing, Sheu Wayne H H, Yokota Mitsuhiro, Wu Jer-Yuarn, Cheng Ching-Yu, Wong Tien-Yin, Shu Xiao-Ou, Kato Norihiro, Park Kyong-Soo, Tai E-Shyong, Matsuda Fumihiko, Koh Woon-Puay, Ma Ronald C W, Maeda Shiro, Millwood Iona Y, Lee Juyoung, Kadowaki Takashi, Walters Robin G, Kim Bong-Jo, Mohlke Karen L, Sim Xueling

Аннотация

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes-NKX6-3 and ANK1-in different tissues4-6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways.

Identification of type 2 diabetes loci in 433,540 East Asian individuals.

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