European journal of epidemiology · 2020

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood.

СтатьяНазвание и аннотация: Перевод в очереди

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Zheng Yan, Huang Tao, Wang Tiange, Mei Zhendong, Sun Zhonghan, Zhang Tao, Ellervik Christina, Chai Jin-Fang, Sim Xueling, van Dam Rob M, Tai E-Shyong, Koh Woon-Puay, Dorajoo Rajkumar, Saw Seang-Mei, Sabanayagam Charumathi, Wong Tien Yin, Gupta Preeti, Rossing Peter, Ahluwalia Tarunveer S, Vinding Rebecca K, Bisgaard Hans, Bønnelykke Klaus, Wang Yujie, Graff Mariaelisa, Voortman Trudy, van Rooij Frank J A, Hofman Albert, van Heemst Diana, Noordam Raymond, Estampador Angela C, Varga Tibor V, Enzenbach Cornelia, Scholz Markus, Thiery Joachim, Burkhardt Ralph, Orho-Melander Marju, Schulz Christina-Alexandra, Ericson Ulrika, Sonestedt Emily, Kubo Michiaki, Akiyama Masato, Zhou Ang, Kilpeläinen Tuomas O, Hansen Torben, Kleber Marcus E, Delgado Graciela, McCarthy Mark, Lemaitre Rozenn N, Felix Janine F, Jaddoe Vincent W V, Wu Ying, Mohlke Karen L, Lehtimäki Terho, Wang Carol A, Pennell Craig E, Schunkert Heribert, Kessler Thorsten, Zeng Lingyao, Willenborg Christina, Peters Annette, Lieb Wolfgang, Grote Veit, Rzehak Peter, Koletzko Berthold, Erdmann Jeanette, Munz Matthias, Wu Tangchun, He Meian, Yu Caizheng, Lecoeur Cécile, Froguel Philippe, Corella Dolores, Moreno Luis A, Lai Chao-Qiang, Pitkänen Niina, Boreham Colin A, Ridker Paul M, Rosendaal Frits R, de Mutsert Renée, Power Chris, Paternoster Lavinia, Sørensen Thorkild I A, Tjønneland Anne, Overvad Kim, Djousse Luc, Rivadeneira Fernando, Lee Nanette R, Raitakari Olli T, Kähönen Mika, Viikari Jorma, Langhendries Jean-Paul, Escribano Joaquin, Verduci Elvira, Dedoussis George, König Inke, Balkau Beverley, Coltell Oscar, Dallongeville Jean, Meirhaeghe Aline, Amouyel Philippe, Gottrand Frédéric, Pahkala Katja, Niinikoski Harri, Hyppönen Elina, März Winfried, Mackey David A, Gruszfeld Dariusz, Tucker Katherine L, Fumeron Frédéric, Estruch Ramon, Ordovas Jose M, Arnett Donna K, Mook-Kanamori Dennis O, Mozaffarian Dariush, Psaty Bruce M, North Kari E, Chasman Daniel I, Qi Lu

Аннотация

Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide association data from EGG consortium of 153,781 participants, ICBP consortium and UK Biobank cohort together of 757,601 participants. We used seven SNPs as the instrumental variable in the study-level analysis and 47 SNPs in the summary-level analysis. In the study-level analyses, decreased birthweight was associated with a higher risk of hypertension in adults (the odds ratio per 1 standard deviation (SD) lower birthweight, 1.22; 95% CI 1.16 to 1.28), while no association was found between genetically instrumented birthweight and hypertension risk (instrumental odds ratio for causal effect per 1 SD lower birthweight, 0.97; 95% CI 0.68 to 1.41). Such results were consistent with that from the summary-level analyses, where the genetically determined low birthweight was not associated with blood pressure measurements either. One SD lower genetically determined birthweight was not associated with systolic blood pressure (β = - 0.76, 95% CI - 2.45 to 1.08 mmHg), 0.06 mmHg lower diastolic blood pressure (β = - 0.06, 95% CI - 0.93 to 0.87 mmHg), or pulse pressure (β = - 0.65, 95% CI - 1.38 to 0.69 mmHg, all p > 0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.

Предметные рубрики MeSH

Adult Birth Weight Blood Pressure Body Mass Index Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Hypertension Infant, Low Birth Weight Infant, Newborn Male Mendelian Randomization Analysis Polymorphism, Single Nucleotide

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH