Experimental gerontology · 2025
Mediating effect of physical activity on the association between body fat distribution, dysmobility syndrome, and cognitive impairment in older women in the community.
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Kim Minjun, Lee Inhwan
Аннотация
PURPOSE: To examine the association between body fat distribution, dysmobility syndrome, and cognitive impairment in 181 community-dwelling older women and assess physical activity's mediating role.
METHODS: Body composition was assessed using dual-energy X-ray absorptiometry, and the android-to-gynoid (A/G) fat ratio was calculated as the android fat proportion divided by the gynoid fat proportion. Participants were categorized into high and low 50 % groups based on the A/G fat ratio. Dysmobility syndrome was defined as the presence of at least three of the following: increased body fat percentage, decreased muscle mass, osteoporosis, slow gait speed, reduced grip strength, or a history of falls. Cognitive impairment was defined as a Mini-Mental State Examination for Dementia Screening score ≤ 23. Physical activity was measured using the International Physical Activity Questionnaire, with ≥600 metabolic equivalent of task-minutes per week classified as active and < 600 as inactive. Binary logistic regression was used to compute odds ratios (OR) and 95 % confidence intervals (CI) for the A/G fat ratio and physical activity. The mediating effects of physical activity were analyzed using Process Macro Model 4.
RESULTS: Participants in the low 50 % A/G fat ratio group had higher odds of dysmobility syndrome (crude OR = 3.500, p < 0.001; adjusted OR = 3.678, p = 0.002) and cognitive impairment (crude OR = 2.714, p = 0.005; adjusted OR = 3.293, p = 0.005) than did those in the high 50 % group, even after covariate adjustments. The inactive group had higher odds of dysmobility syndrome (crude OR = 4.185, p < 0.001; adjusted OR = 3.199, p = 0.005) and cognitive impairment (crude OR = 3.190, p = 0.001; adjusted OR = 2.551, p = 0.022) than did the active group. Mediation analysis indicated that physical activity partially mediated the association between the A/G fat ratio and dysmobility syndrome (indirect effect = -0.5099, 95 % CI = -0.9045 to -0.1786) and cognitive impairment (indirect effect = 0.1446, 95 % CI = 0.0554 to 0.2582).
CONCLUSION: A lower A/G fat ratio increases the risks of dysmobility syndrome and cognitive impairment in older women; physical activity may mitigate these effects.
METHODS: Body composition was assessed using dual-energy X-ray absorptiometry, and the android-to-gynoid (A/G) fat ratio was calculated as the android fat proportion divided by the gynoid fat proportion. Participants were categorized into high and low 50 % groups based on the A/G fat ratio. Dysmobility syndrome was defined as the presence of at least three of the following: increased body fat percentage, decreased muscle mass, osteoporosis, slow gait speed, reduced grip strength, or a history of falls. Cognitive impairment was defined as a Mini-Mental State Examination for Dementia Screening score ≤ 23. Physical activity was measured using the International Physical Activity Questionnaire, with ≥600 metabolic equivalent of task-minutes per week classified as active and < 600 as inactive. Binary logistic regression was used to compute odds ratios (OR) and 95 % confidence intervals (CI) for the A/G fat ratio and physical activity. The mediating effects of physical activity were analyzed using Process Macro Model 4.
RESULTS: Participants in the low 50 % A/G fat ratio group had higher odds of dysmobility syndrome (crude OR = 3.500, p < 0.001; adjusted OR = 3.678, p = 0.002) and cognitive impairment (crude OR = 2.714, p = 0.005; adjusted OR = 3.293, p = 0.005) than did those in the high 50 % group, even after covariate adjustments. The inactive group had higher odds of dysmobility syndrome (crude OR = 4.185, p < 0.001; adjusted OR = 3.199, p = 0.005) and cognitive impairment (crude OR = 3.190, p = 0.001; adjusted OR = 2.551, p = 0.022) than did the active group. Mediation analysis indicated that physical activity partially mediated the association between the A/G fat ratio and dysmobility syndrome (indirect effect = -0.5099, 95 % CI = -0.9045 to -0.1786) and cognitive impairment (indirect effect = 0.1446, 95 % CI = 0.0554 to 0.2582).
CONCLUSION: A lower A/G fat ratio increases the risks of dysmobility syndrome and cognitive impairment in older women; physical activity may mitigate these effects.