International journal of nanomedicine · 2026
Bioactive Platinum Nanozymes Accelerate Diabetic Wound Healing via Anti-Inflammation and Macrophage Polarization Modulation.
СтатьяНазвание и аннотация: Перевод в очереди
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Shi Liyong, Cheng Jing, Lin Lianshun, Liu Tanwei, Chen Linlin, Wang Xiali, Cai Suqin, Qiu Liliang, Chen Miaoxiang, Chen Qidong, Zhong Fanbin, Yan Furong, Chen Xiaoyang, Zeng Yiming
Аннотация
PURPOSE: This study aims to develop a therapeutic agent that accelerates the healing of chronic diabetic wounds by harnessing the highly efficient enzyme-mimicking activity of platinum nanozymes, and to elucidate its underlying mechanisms, thereby offering new insights for the treatment of diabetic wounds.
METHODS: SHA-PtNPs were synthesized using sodium hyaluronate (SHA) as the carrier, and their structural features were characterized by XRD, TEM, XPS and FTIR. The composite was then applied to evaluate wound-healing efficacy in diabetic mice. Furthermore, H&E staining, immunofluorescence staining, and other analyses were employed to investigate its underlying mechanisms in promoting wound repair.
RESULTS: The results revealed that SHA-PtNPs significantly accelerated wound closure through multiple mechanisms: (1) effective suppression of inflammatory responses and related cytokine production; (2) promotion of TGF-β1 secretion and upregulation of CD31 and α-SMA expression, thereby enhancing angiogenesis and tissue contraction; and (3) induction of macrophage polarization from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype.
CONCLUSION: These findings suggest that SHA-PtNPs, as a nanozyme-based material, hold great potential as an efficient therapeutic agent for diabetic wound healing, demonstrating a synergistic mechanism that integrates ROS regulation with immune microenvironment modulation.
METHODS: SHA-PtNPs were synthesized using sodium hyaluronate (SHA) as the carrier, and their structural features were characterized by XRD, TEM, XPS and FTIR. The composite was then applied to evaluate wound-healing efficacy in diabetic mice. Furthermore, H&E staining, immunofluorescence staining, and other analyses were employed to investigate its underlying mechanisms in promoting wound repair.
RESULTS: The results revealed that SHA-PtNPs significantly accelerated wound closure through multiple mechanisms: (1) effective suppression of inflammatory responses and related cytokine production; (2) promotion of TGF-β1 secretion and upregulation of CD31 and α-SMA expression, thereby enhancing angiogenesis and tissue contraction; and (3) induction of macrophage polarization from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype.
CONCLUSION: These findings suggest that SHA-PtNPs, as a nanozyme-based material, hold great potential as an efficient therapeutic agent for diabetic wound healing, demonstrating a synergistic mechanism that integrates ROS regulation with immune microenvironment modulation.