The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods.
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Thornton Laura M, Munn-Chernoff Melissa A, Baker Jessica H, Juréus Anders, Parker Richard, Henders Anjali K, Larsen Janne T, Petersen Liselotte, Watson Hunna J, Yilmaz Zeynep, Kirk Katherine M, Gordon Scott, Leppä Virpi M, Martin Felicity C, Whiteman David C, Olsen Catherine M, Werge Thomas M, Pedersen Nancy L, Kaye Walter, Bergen Andrew W, Halmi Katherine A, Strober Michael, Kaplan Allan S, Woodside D Blake, Mitchell James, Johnson Craig L, Brandt Harry, Crawford Steven, Horwood L John, Boden Joseph M, Pearson John F, Duncan Laramie E, Grove Jakob, Mattheisen Manuel, Jordan Jennifer, Kennedy Martin A, Birgegård Andreas, Lichtenstein Paul, Norring Claes, Wade Tracey D, Montgomery Grant W, Martin Nicholas G, Landén Mikael, Mortensen Preben Bo, Sullivan Patrick F, Bulik Cynthia M
Аннотация
METHODS: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H.
RESULTS: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable.
CONCLUSIONS: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.