X-ray responsive therapeutic systems in tumor treatments.

Due to its high energy and deep tissue penetration, X-ray is an ideal stimulus source for diagnosis and therapy. In the field of cancer treatment, by reasonably designing and using systems with X-ray responsiveness, it is possible to improve treatment methods or combine multiple treatment modalities, thereby improving treatment effectiveness and reducing side effects. This review aims to summarize the research progress of X-ray responsiveness in the field of cancer treatment in recent years. Specifically, it introduces the promotion of X-ray responsive radiosensitizers on X-ray radiation therapy itself, as well as the combination of radiotherapy and other cancer therapies mediated by X-ray responsive therapeutic systems, which mainly includes the combination of radiotherapy and photodynamic therapy through X-ray responsive scintillators and the combination of radiotherapy and chemotherapy through X-ray responsive drug delivery systems.