DOI 10.2807/1560-7917.es.2025.30.45.2500816

Медицинская библиотека · Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025

Effectiveness of long-acting monoclonal antibodies against laboratory-confirmed RSV in children aged < 24 months and hospitalised for severe acute respiratory infection, European pilot study, 2024 to 2025.

Savulescu Camelia, Ganser Iris, Nicolay Nathalie, Lajot Adrien, Campos Sandra, Martínez-Baz Iván, Rodrigues Ana Paula, Vandromme Mathil, Cara-Rodríguez Marta, Echeverría Aitziber, Gaio Vânia, Parsy Marie-Pierre, Roldan Garrido Ana, Castilla Jesús, Guiomar Raquel, Bacci Sabrina, Rose Angela Mc, VEBIS hospital network RSV IE group

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Аннотация

We measured effectiveness of nirsevimab against laboratory-confirmed respiratory syncytial virus (RSV) infection in a test-negative case-control study among children aged < 24 months hospitalised for severe acute respiratory infection in three European countries. The overall effectiveness in the 2024/25 season among 2,201 children was 79% (95% CI: 58 to 89) and 85%, 78% and 69% at < 30, 30-89 and 90-215 days since immunisation. Immunisation was effective for preventing RSV-related hospitalisation in children, but effectiveness by time since immunisation needs monitoring in future seasons.

Для цитирования: Savulescu Camelia, Ganser Iris, Nicolay Nathalie, Lajot Adrien, Campos Sandra, Martínez-Baz Iván, Rodrigues Ana Paula, Vandromme Mathil, Cara-Rodríguez Marta, Echeverría Aitziber, Gaio Vânia, Parsy Marie-Pierre, Roldan Garrido Ana, Castilla Jesús, Guiomar Raquel, Bacci Sabrina, Rose Angela Mc, VEBIS hospital network RSV IE group. Effectiveness of long-acting monoclonal antibodies against laboratory-confirmed RSV in children aged < 24 months and hospitalised for severe acute respiratory infection, European pilot study, 2024 to 2025.. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2025. DOI: 10.2807/1560-7917.es.2025.30.45.2500816.

Предметные рубрики MeSH

Humans Respiratory Syncytial Virus Infections Infant Pilot Projects Hospitalization Male Female Europe Case-Control Studies Respiratory Syncytial Virus, Human Respiratory Tract Infections Antibodies, Monoclonal, Humanized Child, Preschool Antiviral Agents Treatment Outcome Respiratory Syncytial Viruses Seasons Acute Disease Palivizumab

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