The Journal of antimicrobial chemotherapy · 2025
Decrease in colistin resistance among young bovine and pig productions in France: relationship with colistin usage and stewardship measures.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Chauvin Claire, Jouy Eric, Chevance Anne, Jaureguy Corinne, Sauzea Xavier, Jarrige Nathalie, Cazeau Géraldine, Perrin-Guyomard Agnès, Chanteperdrix Magdéléna, Hemonic Anne, Poissonnet Alexandre, Urban Delphine
Аннотация
BACKGROUND: Colistin is a last-line antibiotic used to treat multiresistant human infections. The emergence of resistance in animal productions led to recommendations to reduce the veterinary use of colistin over the last decade. A long-term evaluation of policies on colistin usage is now deemed necessary.
OBJECTIVES: This study aims to identify the stewardship measures regarding colistin usage in pig and bovine productions in France and characterize their long-term effects on colistin use and resistance.
METHODS: Measures contributing to colistin stewardship were inventoried from regulators, stakeholders and professionals. Data were collected from antimicrobial usage monitoring systems (i.e. national sales and on-farm usage) and two resistance surveillance programmes (one dedicated to clinical isolates and the other to commensal ones). Two time series-one of animal exposure to colistin and the other showing corresponding Escherichia coli resistance-and their relationships were analysed for the 2008-23 period.
RESULTS: Numerous different stewardship measures were progressively implemented in France during the study period. Colistin exposure significantly decreased in both bovine and pig productions, reaching a plateau in recent years. Colistin resistance concomitantly and markedly decreased, both time series being significantly associated.
CONCLUSIONS: The long-term data available in France on colistin use and colistin resistance enabled analysis of the long-term impact of stewardship measures on the exposure of pigs and cattle, together with bacterial resistance to colistin. Both have significantly decreased towards a plateau, reflecting the effectiveness of the measures adopted to preserve colistin's usefulness in animal and human health.
OBJECTIVES: This study aims to identify the stewardship measures regarding colistin usage in pig and bovine productions in France and characterize their long-term effects on colistin use and resistance.
METHODS: Measures contributing to colistin stewardship were inventoried from regulators, stakeholders and professionals. Data were collected from antimicrobial usage monitoring systems (i.e. national sales and on-farm usage) and two resistance surveillance programmes (one dedicated to clinical isolates and the other to commensal ones). Two time series-one of animal exposure to colistin and the other showing corresponding Escherichia coli resistance-and their relationships were analysed for the 2008-23 period.
RESULTS: Numerous different stewardship measures were progressively implemented in France during the study period. Colistin exposure significantly decreased in both bovine and pig productions, reaching a plateau in recent years. Colistin resistance concomitantly and markedly decreased, both time series being significantly associated.
CONCLUSIONS: The long-term data available in France on colistin use and colistin resistance enabled analysis of the long-term impact of stewardship measures on the exposure of pigs and cattle, together with bacterial resistance to colistin. Both have significantly decreased towards a plateau, reflecting the effectiveness of the measures adopted to preserve colistin's usefulness in animal and human health.