Journal of applied microbiology · 2025
Resveratrol potentiates the antibiofilm and antibacterial activity of polymyxin B against carbapenem-resistant Acinetobacter baumannii.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Yanhong, Wu Bin, Li Yanli, Hu Yanwu, Wang Meijun, Liang Rongxin
Аннотация
AIMS: Polymyxins are generally recommended to be used in combination with other antibiotics for improving their antibacterial effects. As for treating carbapenem-resistant Acinetobacter baumannii infections, which antibiotic is the best option for polymyxin B-based combination therapy is still under debate. Resveratrol, a natural compound that can be well-tolerated by the human body, may have potential value in the polymyxin B-based combination therapy against carbapenem-resistant A. baumannii infections.
METHODS AND RESULTS: With checkerboard assays and time-killing studies, we have found that resveratrol increased the sensitivity of carbapenem-resistant A. baumannii to polymyxin B and enhanced the bactericidal activity of polymyxin B against carbapenem-resistant A. baumannii. With biofilm formation studies, we have confirmed that resveratrol potentiated the antibiofilm activity of polymyxin B and improved its bactericidal activity against the bacterial cells with established biofilms.
CONCLUSIONS: Resveratrol potentiates the antibiofilm and antibacterial activity of polymyxin B against carbapenem-resistant A. baumannii. Polymyxin B used in combination with resveratrol may have better clinical efficacy than polymyxin B monotherapy in the treatment of carbapenem-resistant A. baumannii infections.
METHODS AND RESULTS: With checkerboard assays and time-killing studies, we have found that resveratrol increased the sensitivity of carbapenem-resistant A. baumannii to polymyxin B and enhanced the bactericidal activity of polymyxin B against carbapenem-resistant A. baumannii. With biofilm formation studies, we have confirmed that resveratrol potentiated the antibiofilm activity of polymyxin B and improved its bactericidal activity against the bacterial cells with established biofilms.
CONCLUSIONS: Resveratrol potentiates the antibiofilm and antibacterial activity of polymyxin B against carbapenem-resistant A. baumannii. Polymyxin B used in combination with resveratrol may have better clinical efficacy than polymyxin B monotherapy in the treatment of carbapenem-resistant A. baumannii infections.