Health science reports · 2026
Association of Serum Vitamin D Level and Hematological Inflammatory Indices in Participants of the MASHAD Study.
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Mohtashamian Abbas, Latifi MohammadReza, Nejad Shahrokh Abadi Reza, Kolahi-Ahari Rana, Sahranavard Toktam, Soflaei Sara Saffar, Morovatdar Negar, Noghabi Mohaddeseh Sedaghati, Ferns Gordon A, Rezaee Ramin, Ghayour-Mobarhan Majid
Аннотация
BACKGROUND AND AIM: Vitamin D, a fat-soluble vitamin, has various vital roles in physiological processes. Recent evidence suggests that optimal vitamin D levels may be associated with improved immune function and reduced systemic inflammation. The present study aims to evaluate associations between serum vitamin D levels and various hematological inflammatory indices in participants of the MASHAD cohort study, Mashhad, Iran.
METHODS: This study was designed as a cross-sectional analysis conducted within the framework of phase I of the MASHAD cohort study. Participants (aged ≥ 18 years old and signed an informed consent) were recruited from a defined population, ensuring the representativeness of the sample for evaluation of potential association between serum vitamin D levels and hematological inflammatory indices including Red Cell Distribution Width (RDW-CV), high-sensitivity C-reactive protein (hs-CRP), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), Mean Platelet Volume (MPV), and Platelet Distribution Width (PDW).
RESULTS: A total of 458 participants were included in the current study, comprising 229 males and 229 females. Serum vitamin D had weak correlation with hs-CRP (r = -0.02), SII (r = -0.01), PLR (r = 0.05), NLR (r = 0.01), PDW (r = -0.05), and RDW-CV (r = -0.04). For males, no significant differences were observed in RDW-CV, PDW, MPV, NLR, or PLR across the vitamin D quartiles (p > 0.05 for all comparisons). In contrast, among female participants, significant differences in PDW (p = 0.026) between quartile groups 1 and 4, and marginal significance between quartile 1 and 3 for RDW (p = 0.062) were observed.
CONCLUSION: The current findings revealed a weak association between serum vitamin D concentrations and inflammatory indicators. Among hematological parameters, gender-based differences were observed, with PDW and RDW levels significantly varying between vitamin D quartiles in women.
METHODS: This study was designed as a cross-sectional analysis conducted within the framework of phase I of the MASHAD cohort study. Participants (aged ≥ 18 years old and signed an informed consent) were recruited from a defined population, ensuring the representativeness of the sample for evaluation of potential association between serum vitamin D levels and hematological inflammatory indices including Red Cell Distribution Width (RDW-CV), high-sensitivity C-reactive protein (hs-CRP), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), Mean Platelet Volume (MPV), and Platelet Distribution Width (PDW).
RESULTS: A total of 458 participants were included in the current study, comprising 229 males and 229 females. Serum vitamin D had weak correlation with hs-CRP (r = -0.02), SII (r = -0.01), PLR (r = 0.05), NLR (r = 0.01), PDW (r = -0.05), and RDW-CV (r = -0.04). For males, no significant differences were observed in RDW-CV, PDW, MPV, NLR, or PLR across the vitamin D quartiles (p > 0.05 for all comparisons). In contrast, among female participants, significant differences in PDW (p = 0.026) between quartile groups 1 and 4, and marginal significance between quartile 1 and 3 for RDW (p = 0.062) were observed.
CONCLUSION: The current findings revealed a weak association between serum vitamin D concentrations and inflammatory indicators. Among hematological parameters, gender-based differences were observed, with PDW and RDW levels significantly varying between vitamin D quartiles in women.