Nature communications · 2021
Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Liu Yifei, Wang Bo, Shu Shaohua, Li Zheng, Song Chi, Liu Di, Niu Yan, Liu Jinxin, Zhang Jingjing, Liu Heping, Hu Zhigang, Huang Bisheng, Liu Xiuyu, Liu Wei, Jiang Liping, Alami Mohammad Murtaza, Zhou Yuxin, Ma Yutao, He Xiangxiang, Yang Yicheng, Zhang Tianyuan, Hu Hui, Barker Michael S, Chen Shilin, Wang Xuekui, Nie Jing
Аннотация
Chinese goldthread (Coptis chinensis Franch.), a member of the Ranunculales, represents an important early-diverging eudicot lineage with diverse medicinal applications. Here, we present a high-quality chromosome-scale genome assembly and annotation of C. chinensis. Phylogenetic and comparative genomic analyses reveal the phylogenetic placement of this species and identify a single round of ancient whole-genome duplication (WGD) shared by the Ranunculaceae. We characterize genes involved in the biosynthesis of protoberberine-type alkaloids in C. chinensis. In particular, local genomic tandem duplications contribute to member amplification of a Ranunculales clade-specific gene family of the cytochrome P450 (CYP) 719. The functional versatility of a key CYP719 gene that encodes the (S)-canadine synthase enzyme involved in the berberine biosynthesis pathway may play critical roles in the diversification of other berberine-related alkaloids in C. chinensis. Our study provides insights into the genomic landscape of early-diverging eudicots and provides a valuable model genome for genetic and applied studies of Ranunculales.