Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium.
СтатьяМетаанализПоддержка исследования: вне правительства СШАПоддержка правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Ho Nhan Thi, Abe Sarah Krull, Rahman Md Shafiur, Islam Rashedul, Saito Eiko, Gupta Prakash C, Pednekar Mangesh S, Sawada Norie, Tsugane Shoichiro, Tamakoshi Akiko, Kimura Takashi, Shu Xiao-Ou, Gao Yu-Tang, Koh Woon-Puay, Cai Hui, Wen Wanqing, Sakata Ritsu, Tsuji Ichiro, Malekzadeh Reza, Pourshams Akram, Kanemura Seiki, Kim Jeongseon, Chen Yu, Ito Hidemi, Oze Isao, Nagata Chisato, Wada Keiko, Sugawara Yumi, Park Sue K, Shin Aesun, Yuan Jian-Min, Wang Renwei, Kweon Sun-Seog, Shin Min-Ho, Poustchi Hossein, Vardanjani Hossein Molavi, Ahsan Habibul, Chia Kee Seng, Matsuo Keitaro, Qiao You-Lin, Rothman Nathaniel, Zheng Wei, Inoue Manami, Kang Daehee, Boffetta Paolo
Аннотация
There has been growing evidence suggesting that diabetes may be associated with increased liver cancer risk. However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association between baseline diabetes and liver cancer incidence and mortality. Cox proportional hazard model and competing risk approach was used for pooled data. Two-stage meta-analysis across studies was also done. There were 839,194 subjects with valid data regarding liver cancer incidence (5654 liver cancer cases [48.29/100,000 person-years]), follow-up time and baseline diabetes (44,781 with diabetes [5.3%]). There were 747,198 subjects with valid data regarding liver cancer mortality (5020 liver cancer deaths [44.03/100,000 person-years]), follow-up time and baseline diabetes (43,243 with diabetes [5.8%]). Hazard ratio (HR) (95% confidence interval [95%CI]) of liver cancer diagnosis in those with vs. without baseline diabetes was 1.97 (1.79, 2.16) (p < .0001) after adjusting for baseline age, gender, body mass index, tobacco smoking, alcohol use, and heterogeneity across studies (n = 586,072; events = 4620). Baseline diabetes was associated with increased cumulative incidence of death due to liver cancer (adjusted HR (95%CI) = 1.97 (1.79, 2.18); p < .0001) (n = 595,193; events = 4110). A two-stage meta-analytic approach showed similar results. This paper adds important population-based evidence to current literature regarding the increased incidence and mortality of liver cancer in adults with diabetes. The analysis of data pooled from 20 studies of different Asian countries and the meta-analysis across studies with large number of subjects makes the results robust.