Chemical & pharmaceutical bulletin · 2003
Uncinoside A and B, two new antiviral chromone glycosides from Selaginella uncinata.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ma Ling-Yun, Ma Shuang-Cheng, Wei Feng, Lin Rui-Chao, But Paul Pui-Hay, Lee Spencer Hon-Sun, Lee Song Fong
Аннотация
Five compounds have been isolated from the dried whole plants of Selaginella uncinata, two of them were new chromone glycosides, 5-hydroxy-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside A) and 5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside B). Their structures were elucidated by spectroscopic methods including one- and two-dimensional NMR techniques. The other three compounds were identified as 8-methyl eugenitol, amentoflavone and hinokiflavone. Uncinoside A and B showed potent antiviral activities against respiratory syncytial virus (RSV) with IC(50) value of 6.9 and 1.3 microg/ml, moderate antiviral activities against parainfluenza type 3 virus (PIV 3) with IC(50) value of 13.8 and 20.8 microg/ml, respectively.
Предметные рубрики MeSH
Antiviral AgentsCell SurvivalChromonesCrystallography, X-RayCytopathogenic Effect, ViralHydrolysisMagnetic Resonance SpectroscopyModels, MolecularMolecular ConformationParainfluenza Virus 3, HumanPlant ExtractsRespiratory Syncytial VirusesSelaginellaceaeSpectrometry, Mass, Fast Atom BombardmentSpectrophotometry, InfraredSpectrophotometry, UltravioletVirus Replication