[Study on the preparation of venenum bufonis beta-cyclodextrin inclusion complexes].

OBJECTIVE

To study the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.

METHOD: An optimal condition was established by the uniform design. Under the optimal conditions the Venenum Bufonis beta-cyclodextrin inclusion complexes were prepared with 5 different methods.

RESULT: The ball grinding method was superior to other four methods. The bufadienolide inclusion rate of Venenum Bufonis beta-cyclodextrin prepared with ball grinding method was 85.42%.

CONCLUSION

Ball grinding method is the best method for the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.