Current eye research · 2019
Image Artifacts in Optical Coherence Tomography Angiography Among Patients With Multiple Sclerosis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Iftikhar Mustafa, Zafar Sidra, Gonzalez Natalia, Murphy Olwen, Ohemaa Kwakyi M S, Sydney Feldman B S, A Calabresi Peter, Saidha Shiv, Channa Roomasa
Аннотация
PURPOSE: To evaluate artifacts in optical coherence tomography angiography (OCT-A) images of multiple sclerosis (MS) patients and healthy controls.
MATERIALS AND METHODS: This was a prospective cross-sectional study conducted at the Department of Neurology and the Wilmer Eye Institute at Johns Hopkins Hospital. Subjects included patients with an established diagnosis of MS and healthy volunteers. OCT-A was performed using Spectralis® OCT-A prototype, OCT2 (Heidelberg, Germany). The type and frequency of artifacts, the clinical factors associated with them, and their impact on vessel density measurements were assessed.
RESULTS: Overall, 385 images from 102 participants were analyzed. The majority of images (97.1%) had some degree of artifact. The most frequent was motion artifact (96.3%), followed by blinking (51.9%), and loss of focus (25.1%). MS patients were more likely to have any artifact vs. controls (OR [95% CI], 3.83 [1.12-12.92]), and were more likely to have motion artifacts with longer disease duration (OR [95% CI], 1.11 [1.03-1.20]) or history of optic neuritis (OR [95% CI], 4.24 [1.19-15.16]). The relative area occupied by the artifact was found to underestimate vessel density measurements in both MS patients and controls.
CONCLUSIONS: Artifacts are common with OCT-A imaging using this particular Spectralis® OCT-A prototype and can impact quantitative vascular density metrics. Future studies should review images for artifacts before drawing definitive conclusions.
MATERIALS AND METHODS: This was a prospective cross-sectional study conducted at the Department of Neurology and the Wilmer Eye Institute at Johns Hopkins Hospital. Subjects included patients with an established diagnosis of MS and healthy volunteers. OCT-A was performed using Spectralis® OCT-A prototype, OCT2 (Heidelberg, Germany). The type and frequency of artifacts, the clinical factors associated with them, and their impact on vessel density measurements were assessed.
RESULTS: Overall, 385 images from 102 participants were analyzed. The majority of images (97.1%) had some degree of artifact. The most frequent was motion artifact (96.3%), followed by blinking (51.9%), and loss of focus (25.1%). MS patients were more likely to have any artifact vs. controls (OR [95% CI], 3.83 [1.12-12.92]), and were more likely to have motion artifacts with longer disease duration (OR [95% CI], 1.11 [1.03-1.20]) or history of optic neuritis (OR [95% CI], 4.24 [1.19-15.16]). The relative area occupied by the artifact was found to underestimate vessel density measurements in both MS patients and controls.
CONCLUSIONS: Artifacts are common with OCT-A imaging using this particular Spectralis® OCT-A prototype and can impact quantitative vascular density metrics. Future studies should review images for artifacts before drawing definitive conclusions.