Nature communications · 2018

Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

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Takeuchi Fumihiko, Akiyama Masato, Matoba Nana, Katsuya Tomohiro, Nakatochi Masahiro, Tabara Yasuharu, Narita Akira, Saw Woei-Yuh, Moon Sanghoon, Spracklen Cassandra N, Chai Jin-Fang, Kim Young-Jin, Zhang Liang, Wang Chaolong, Li Huaixing, Li Honglan, Wu Jer-Yuarn, Dorajoo Rajkumar, Nierenberg Jovia L, Wang Ya Xing, He Jing, Bennett Derrick A, Takahashi Atsushi, Momozawa Yukihide, Hirata Makoto, Matsuda Koichi, Rakugi Hiromi, Nakashima Eitaro, Isono Masato, Shirota Matsuyuki, Hozawa Atsushi, Ichihara Sahoko, Matsubara Tatsuaki, Yamamoto Ken, Kohara Katsuhiko, Igase Michiya, Han Sohee, Gordon-Larsen Penny, Huang Wei, Lee Nanette R, Adair Linda S, Hwang Mi Yeong, Lee Juyoung, Chee Miao Li, Sabanayagam Charumathi, Zhao Wanting, Liu Jianjun, Reilly Dermot F, Sun Liang, Huo Shaofeng, Edwards Todd L, Long Jirong, Chang Li-Ching, Chen Chien-Hsiun, Yuan Jian-Min, Koh Woon-Puay, Friedlander Yechiel, Kelly Tanika N, Bin Wei Wen, Xu Liang, Cai Hui, Xiang Yong-Bing, Lin Kuang, Clarke Robert, Walters Robin G, Millwood Iona Y, Li Liming, Chambers John C, Kooner Jaspal S, Elliott Paul, van der Harst Pim, International Genomics of Blood Pressure (iGEN-BP) Consortium, Chen Zhengming, Sasaki Makoto, Shu Xiao-Ou, Jonas Jost B, He Jiang, Heng Chew-Kiat, Chen Yuan-Tsong, Zheng Wei, Lin Xu, Teo Yik-Ying, Tai E-Shyong, Cheng Ching-Yu, Wong Tien Yin, Sim Xueling, Mohlke Karen L, Yamamoto Masayuki, Kim Bong-Jo, Miki Tetsuro, Nabika Toru, Yokota Mitsuhiro, Kamatani Yoichiro, Kubo Michiaki, Kato Norihiro

Аннотация

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

Предметные рубрики MeSH

Asian People Blood Pressure Europe Female Genetic Loci Genome-Wide Association Study Humans Linkage Disequilibrium Male Polymorphism, Single Nucleotide Racial Groups White People

Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

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Аннотация

Предметные рубрики MeSH