Nature medicine · 2024
Global genomic surveillance of monkeypox virus.
СтатьяНазвание и аннотация: Перевод в очереди
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Otieno James R, Ruis Christopher, Onoja Anyebe B, Kuppalli Krutika, Hoxha Ana, Nitsche Andreas, Brinkmann Annika, Michel Janine, Mbala-Kingebeni Placide, Mukadi-Bamuleka Daniel, Osman Muntasir Mohammed, Hussein Hanadi, Raja Muhammad Ali, Fotsing Richard, Herring Belinda L, Keita Mory, Rico Jairo Mendez, Gresh Lionel, Barakat Amal, Katawera Victoria, Nahapetyan Karen, Naidoo Dhamari, Floto R Andres, Cunningham Jane, Van Kerkhove Maria D, Lewis Rosamund F, Subissi Lorenzo
Аннотация
Monkeypox virus (MPXV) is endemic in western and Central Africa, and in May 2022, a clade IIb lineage (B.1) caused a global outbreak outside Africa, resulting in its detection in 116 countries and territories. To understand the global phylogenetics of MPXV, we analyzed all available MPXV sequences, including 10,670 sequences from 65 countries collected between 1958 and 2024. Our analysis reveals high mobility of clade I viruses within Central Africa, sustained human-to-human transmission of clade IIb lineage A viruses within the Eastern Mediterranean region and distinct mutational signatures that can distinguish sustained human-to-human from animal-to-animal transmission. Moreover, distinct clade I sequences from Sudan suggest local MPXV circulation in areas of eastern Africa over the past four decades. Our study underscores the importance of genomic surveillance in tracking spatiotemporal dynamics of MXPV clades and the need to strengthen such surveillance, including in some parts of eastern Africa.