[Vasomotor endothelial dysfunction in young men with grade 1 arterial hypertension].

In order to study vasomotor endothelial function and risk factors of endothelial dysfunction in young men with grade 1 arterial hypertension (G1AH) we examined 76 men with G1AH and 30 healthy men aged 20-40 years. Flow-mediated vasodilatation (FMD) of the brachial artery was assessed by ultrasonic method of Celermajer D.S. Vasomotor endothelial dysfunction (FMD<6%) was found significantly more frequently in men with G1AH than in healthy men (51% vs 13%). In healthy young men with normal blood pressure smoking was the main risk factor of endothelial dysfunction. In young men with G1AH risk factors for endothelial dysfunction were: family history of early cardiovascular disease, smoking, and elevation of low-density cholesterol level. Probability of endothelial dysfunction in the absence of these factors was low - 11%, in the presence of one factor it was 30%, two factors - 60%, and three factors - 83%. Elevated (>14.8%) red blood cell distribution width (RDW) was associated with endothelial dysfunction. Probability of endothelial dysfunction in young men with G1AH and elevated RDW was 5 times greater than in those with normal RDW.