Медицинская библиотека · medRxiv : the preprint server for health sciences · 2024

First imported Cases of MPXV Clade Ib in Goma, Democratic Republic of the Congo: Implications for Global Surveillance and Transmission Dynamics.

Mukadi-Bamuleka Daniel, Kinganda-Lusamaki Eddy, Mulopo-Mukanya Noella, Amuri-Aziza Adrienne, O'Toole Áine, Modadra-Madakpa Brigitte, Ndongala Guy Mutombo, Vakaniaki Emmanuel Hasivirwe, Merritt Sydney, Kacita Cris, Maboko Gaston Lubambo, Makangara-Cigolo Jean-Claude, Ngimba Michel, Lokilo Emmanuel, Pukuta-Simbu Elisabeth, Luakanda Gradi, Bodisa-Matamu Tavia, Kalimuli Zephanie Paluku, Akil-Bandali Prince, Kavira Sifa, Jansen Daan, Kamaliro Adèle Kavira, Muhindo-Milonde Emile, Mufungizi Jeriel, Hamisi Yves Birindwa, Kavunga Hugo, Tshiani Olivier, Nundu Sabin S, Liesenborghs Laurens, Hoff Nicole A, Nachega Jean, Shongo Robert, Ayouba Ahidjo, Pilarowski Genay, Mangolopa Alain Kakule, Ebondo Amos Kiuka, Low Nicola, Shaw Souradet Y, Wilkinson Sam, Tessema Sofonias Kifle, Subissi Lorenzo, Delaporte Eric, Vercauteren Koen, Wawina-Bokalanga Tony, Rimoin Anne W, Peeters Martine, Loman Nicholas, Rambaut Andrew, Muyembe-Tamfum Jean-Jacques, Hensley Lisa E, Kindrachuk Jason, Mbala-Kingebeni Placide, Ahuka-Mundeke Steve

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Аннотация

The ongoing national mpox outbreak in the Democratic Republic of the Congo has resulted in more >30,000 suspected cases in the country from January 2023 to August 2024. While these historic case totals have been driven by primarily by zoonosis, the emergence of Clade Ib monkeypox virus (MPXV), which is connected to more sustained human-to-human transmission, has been associated with increasing public health impacts in eastern DRC. First identified in South Kivu province, Clade Ib MPXV has been identified in multiple non-endemic East African countries for the first time. In DRC, there have been concerns over broader Clade Ib expansion in the country that could further complicate containment and mitigation responses. Here, we report the first introductions of Clade Ib into North Kivu province, including within internal displacement camps, with suspected close contact transmission that includes non-intimate contacts and children. These findings demonstrate that mpox case investigations and community messaging campaigns should include considerations for non-sexual contact-mediated transmission of Clade Ib that includes children <15 years.

Для цитирования: Mukadi-Bamuleka Daniel, Kinganda-Lusamaki Eddy, Mulopo-Mukanya Noella, Amuri-Aziza Adrienne, O'Toole Áine, Modadra-Madakpa Brigitte, Ndongala Guy Mutombo, Vakaniaki Emmanuel Hasivirwe, Merritt Sydney, Kacita Cris, Maboko Gaston Lubambo, Makangara-Cigolo Jean-Claude, Ngimba Michel, Lokilo Emmanuel, Pukuta-Simbu Elisabeth, Luakanda Gradi, Bodisa-Matamu Tavia, Kalimuli Zephanie Paluku, Akil-Bandali Prince, Kavira Sifa, Jansen Daan, Kamaliro Adèle Kavira, Muhindo-Milonde Emile, Mufungizi Jeriel, Hamisi Yves Birindwa, Kavunga Hugo, Tshiani Olivier, Nundu Sabin S, Liesenborghs Laurens, Hoff Nicole A, Nachega Jean, Shongo Robert, Ayouba Ahidjo, Pilarowski Genay, Mangolopa Alain Kakule, Ebondo Amos Kiuka, Low Nicola, Shaw Souradet Y, Wilkinson Sam, Tessema Sofonias Kifle, Subissi Lorenzo, Delaporte Eric, Vercauteren Koen, Wawina-Bokalanga Tony, Rimoin Anne W, Peeters Martine, Loman Nicholas, Rambaut Andrew, Muyembe-Tamfum Jean-Jacques, Hensley Lisa E, Kindrachuk Jason, Mbala-Kingebeni Placide, Ahuka-Mundeke Steve. First imported Cases of MPXV Clade Ib in Goma, Democratic Republic of the Congo: Implications for Global Surveillance and Transmission Dynamics.. medRxiv : the preprint server for health sciences. 2024. DOI: 10.1101/2024.09.12.24313188.

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