Contemporary clinical trials · 2011
Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair.
Историческая статьяСтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Luijendijk Paul, Bouma Berto J, Vriend Joris W J, Groenink Maarten, Vliegen Hubert W, de Groot Eric, Pieper Petronella G, van Dijk Arie P J, Sieswerda Gertjan T, Veen Gerrit, Zwinderman Aeilko H, Mulder Barbara J M
Аннотация
BACKGROUND: HMG-coA-reductase-inhibitors (statins) have been proven to reduce atherosclerosis progression as observed by carotid intima-media thickness in patients with known coronary heart disease, independent of lipid lowering. Cardiovascular complications are common in patients after successful coarctation repair. The effect of statins on cardiovascular risk in adults after successful coarctation repair has not yet been established.
METHODS: We designed a multicentre, prospective, randomised, open label trial to evaluate the effect of the HMGcoA-reductase-inhibitor (Atorvastatin) on atherosclerotic progression in adult post-coarctectomy patients. The primary endpoint in this study is the carotid intima-media thickness as measured by Bmode ultrasonography of the carotid arteries.
CONCLUSION: This large prospective, randomised, open label trial will establish the effect of HMG-coA-reductase inhibitors (Atorvastatin) on cardiovascular risk in adult patients after successful coarctation repair.
METHODS: We designed a multicentre, prospective, randomised, open label trial to evaluate the effect of the HMGcoA-reductase-inhibitor (Atorvastatin) on atherosclerotic progression in adult post-coarctectomy patients. The primary endpoint in this study is the carotid intima-media thickness as measured by Bmode ultrasonography of the carotid arteries.
CONCLUSION: This large prospective, randomised, open label trial will establish the effect of HMG-coA-reductase inhibitors (Atorvastatin) on cardiovascular risk in adult patients after successful coarctation repair.
Предметные рубрики MeSH
AdultAortic CoarctationAtherosclerosisAtorvastatinCardiac Surgical ProceduresCarotid ArteriesDisease ProgressionDose-Response Relationship, DrugFemaleFollow-Up StudiesHeptanoic AcidsHistory, AncientHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMalePostoperative CareProspective StudiesPyrrolesTreatment OutcomeUltrasonography