Nature communications · 2023
Fatty acid desaturation and lipoxygenase pathways support trained immunity.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ferreira Anaísa V, Alarcon-Barrera Juan Carlos, Domínguez-Andrés Jorge, Bulut Özlem, Kilic Gizem, Debisarun Priya A, Röring Rutger J, Özhan Hatice N, Terschlüsen Eva, Ziogas Athanasios, Kostidis Sarantos, Mohammed Yassene, Matzaraki Vasiliki, Renieris George, Giamarellos-Bourboulis Evangelos J, Netea Mihai G, Giera Martin
Аннотация
Infections and vaccines can induce enhanced long-term responses in innate immune cells, establishing an innate immunological memory termed trained immunity. Here, we show that monocytes with a trained immunity phenotype, due to exposure to the Bacillus Calmette-Guérin (BCG) vaccine, are characterized by an increased biosynthesis of different lipid mediators (LM) derived from long-chain polyunsaturated fatty acids (PUFA). Pharmacological and genetic approaches show that long-chain PUFA synthesis and lipoxygenase-derived LM are essential for the BCG-induced trained immunity responses of human monocytes. Furthermore, products of 12-lipoxygenase activity increase in monocytes of healthy individuals after BCG vaccination. Grasping the underscoring lipid metabolic pathways contributes to our understanding of trained immunity and may help to identify therapeutic tools and targets for the modulation of innate immune responses.