Nature microbiology · 2023
Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Larson Erica C, Ellis-Connell Amy L, Rodgers Mark A, Gubernat Abigail K, Gleim Janelle L, Moriarty Ryan V, Balgeman Alexis J, Ameel Cassaundra L, Jauro Solomon, Tomko Jaime A, Kracinovsky Kara B, Maiello Pauline, Borish H Jake, White Alexander G, Klein Edwin, Bucsan Allison N, Darrah Patricia A, Seder Robert A, Roederer Mario, Lin Philana Ling, Flynn JoAnne L, O'Connor Shelby L, Scanga Charles A
Аннотация
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille Calmette-Guérin (BCG) delivery is the only licensed vaccine against tuberculosis; however, it offers little protection from pulmonary tuberculosis in adults and is contraindicated in people living with HIV. Intravenous BCG confers protection against Mtb infection in rhesus macaques; we hypothesized that it might prevent tuberculosis in simian immunodeficiency virus (SIV)-infected macaques, a model for HIV infection. Here intravenous BCG-elicited robust airway T cell influx and elevated plasma and airway antibody titres in both SIV-infected and naive animals. Following Mtb challenge, all 7 vaccinated SIV-naive and 9 out of 12 vaccinated SIV-infected animals were protected, without any culturable bacteria detected from tissues. Peripheral blood mononuclear cell responses post-challenge indicated early clearance of Mtb in vaccinated animals, regardless of SIV infection. These data support that intravenous BCG is immunogenic and efficacious in SIV-infected animals.