iScience · 2023
BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine.
СтатьяНазвание и аннотация: Перевод в очереди
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Perera Dilhan J, Domenech Pilar, Babuadze George Giorgi, Naghibosadat Maedeh, Alvarez Fernando, Koger-Pease Cal, Labrie Lydia, Stuible Matthew, Durocher Yves, Piccirillo Ciriaco A, Lametti André, Fiset Pierre Olivier, Elahi Seyyed Mehdy, Kobinger Gary P, Gilbert Rénald, Olivier Martin, Kozak Robert, Reed Michael B, Ndao Momar
Аннотация
Recent publications have explored intranasal (i.n.) adenovirus-based (Ad) vaccines as an effective strategy for SARS-CoV-2 in pre-clinical models. However, the effects of prior immunizations and infections have yet to be considered. Here, we investigate the immunomodulatory effects of Mycobacterium bovis BCG pre-immunization followed by vaccination with an S-protein-expressing i.n. Ad, termed Ad(Spike). While i.n. Ad(Spike) retains some protective effect after 6 months, a single administration of BCG-Danish prior to Ad(Spike) potentiates its ability to control viral replication of the B.1.351 SARS-CoV-2 variant within the respiratory tract. Though BCG-Danish did not affect Ad(Spike)-generated humoral immunity, it promoted the generation of cytotoxic/Th1 responses over suppressive FoxP3+ TREG cells in the lungs of infected mice. Thus, this vaccination strategy may prove useful in limiting future pandemics by potentiating the long-term efficacy of mucosal vaccines within the context of the widely distributed BCG vaccine.