Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023
Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод в очереди
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Spisarova Martina, Losse Stanislav, Jakubec Petr, Hartmann Igor, Kral Milan, Ehrmann Jiri, Szkorupa Marek, Studentova Hana, Melichar Bohuslav
Аннотация
OBJECTIVE: Intravesical administration of bacillus Calmette-Guérin is standard adjuvant treatment of non-muscle invasive bladder cancer. In spite of the fact that this immunotherapy is locoregional, there are still risk of some complications.
METHODS: We describe two cases of systemic BCG infection after intravesical administration of BCG vaccine in patients with early stage of bladder cancer.
RESULTS: Both patients suffered from systemic BCG infection manifesting as BCG pneumonitis. After standard therapy with antituberculotic agents, both of them fully recovered.
CONCLUSION: BCG infection can occur as a rare but potentially serious complication of this treatment procedure. Gravity of this side effect and its specific therapy require prompt and right diagnosis.
METHODS: We describe two cases of systemic BCG infection after intravesical administration of BCG vaccine in patients with early stage of bladder cancer.
RESULTS: Both patients suffered from systemic BCG infection manifesting as BCG pneumonitis. After standard therapy with antituberculotic agents, both of them fully recovered.
CONCLUSION: BCG infection can occur as a rare but potentially serious complication of this treatment procedure. Gravity of this side effect and its specific therapy require prompt and right diagnosis.