Cell reports · 2020
BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Moorlag Simone J C F M, Rodriguez-Rosales Yessica Alina, Gillard Joshua, Fanucchi Stephanie, Theunissen Kate, Novakovic Boris, de Bont Cynthia M, Negishi Yutaka, Fok Ezio T, Kalafati Lydia, Verginis Panayotis, Mourits Vera P, Koeken Valerie A C M, de Bree L Charlotte J, Pruijn Ger J M, Fenwick Craig, van Crevel Reinout, Joosten Leo A B, Joosten Irma, Koenen Hans, Mhlanga Musa M, Diavatopoulos Dimitri A, Chavakis Triantafyllos, Netea Mihai G
Аннотация
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies have revealed that the induction of trained immunity is associated with a bias toward granulopoiesis in bone marrow hematopoietic progenitor cells, but it is unknown whether BCG vaccination also leads to functional reprogramming of mature neutrophils. Here, we show that BCG vaccination of healthy humans induces long-lasting changes in neutrophil phenotype, characterized by increased expression of activation markers and antimicrobial function. The enhanced function of human neutrophils persists for at least 3 months after vaccination and is associated with genome-wide epigenetic modifications in trimethylation at histone 3 lysine 4. Functional reprogramming of neutrophils by the induction of trained immunity might offer novel therapeutic strategies in clinical conditions that could benefit from modulation of neutrophil effector function.