Disposition of Work-Related Asthma in a Spanish Asthma Cohort: Comparison of Asthma Severity Between Employed and Retired Workers.
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Romero-Mesones Christian, Cruz Maria-Jesus, Alobid Isam, Barroso Blanca, Arismendi Ebymar, Barranco Pilar, Betancor Diana, Bobolea Irina, Cárdaba Blanca, Curto Elena, Domenech Gemma, Domínguez-Ortega Javier, Espejo David, González-Barcala Francisco-Javier, Luna-Porta Juan-Alberto, Martínez-Rivera Carlos, Méndez-Brea Paula, Mullol Joaquim, Olaguibel José-María, Picado Cesar, Plaza Vicente, Del Pozo Victoria, Quirce Santiago, Rial Manuel-Jorge, Rodrigo-Muñoz José-María, Sastre Joaquin, Serrano Sandra, Soto-Retes Lorena, Valero Antonio, Valverde-Monge Marcela, Munoz Xavier
Аннотация
OBJECTIVE: To assess the influence of occupation on asthma in real life and analyze the characteristics of patients with WRA included in an asthma cohort.
METHODS: This was a prospective multicenter study of a cohort of consecutive patients with asthma. A standardized clinical history was completed. Patients were classified as having WRA or non-WRA. All patients underwent respiratory function tests, FeNO test, and methacholine challenge (methacholine concentration that causes a 20% drop in FEV1) at the beginning of the study. They were classified into two groups, depending on their employment status: employed (group 1) or unemployed (group 2).
RESULTS: Of the 480 patients included in the cohort, 82 (17%) received the diagnosis of WRA. Fifty-seven patients (70%) were still working. Mean age (SD) was 46 (10.69) years in group 1 and 57 (9.91) years in group 2 (P < .0001). Significant differences were observed in adherence to treatment (64.9% in group 1 vs 88% in group 2; P = .0354) and in severe asthma exacerbations (35.7% in group 1 vs 0% in group 2; P = .0172). No significant differences were observed in the rest of the variables analyzed.
CONCLUSIONS: The burden of WRA in specialized asthma units is not negligible. The absence of differences in the severity of asthma, the treatment administered, alterations in lung function, and the number of exacerbations in those working versus not working may support the idea that advice regarding changing jobs should be customized for individual patients.