Nature communications · 2019
Outcomes of controlled human malaria infection after BCG vaccination.
Клиническое исследование I фазыСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Walk Jona, de Bree L Charlotte J, Graumans Wouter, Stoter Rianne, van Gemert Geert-Jan, van de Vegte-Bolmer Marga, Teelen Karina, Hermsen Cornelus C, Arts Rob J W, Behet Marije C, Keramati Farid, Moorlag Simone J C F M, Yang Annie S P, van Crevel Reinout, Aaby Peter, de Mast Quirijn, van der Ven André J A M, Stabell Benn Christine, Netea Mihai G, Sauerwein Robert W
Аннотация
Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed 'trained immunity'. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy male and female volunteers to evaluate the induction of immunity and protective efficacy of the anti-tuberculosis BCG vaccine against a controlled human malaria infection. After malaria challenge infection, BCG vaccinated volunteers present with earlier and more severe clinical adverse events, and have significantly earlier expression of NK cell activation markers and a trend towards earlier phenotypic monocyte activation. Furthermore, parasitemia in BCG vaccinated volunteers is inversely correlated with increased phenotypic NK cell and monocyte activation. The combined data demonstrate that BCG vaccination alters the clinical and immunological response to malaria, and form an impetus to further explore its potential in strategies for clinical malaria vaccine development.
Предметные рубрики MeSH
AdolescentAdultAnimalsAnophelesB7-2 AntigenBCG VaccineC-Reactive ProteinCytokinesFemaleGPI-Linked ProteinsGranzymesHLA-DR AntigensHumansImmunity, InnateImmunologic MemoryInterferon-gammaKiller Cells, NaturalLymphocyte ActivationMalaria, FalciparumMaleParasitemiaPlasmodium falciparumReceptors, IgGVaccinationYoung Adult