Revista da Sociedade Brasileira de Medicina Tropical · 2018
Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Peleteiro Thaís Silva, Oliveira Evelin Santos, Conceição Elisabete Lopes, Nascimento-Sampaio Francisco, Alcântara-Neves Neuza Maria, Mendes Carlos Mauricio Cardeal, Bessa Theolis Costa Barbosa
Аннотация
INTRODUCTION: Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection.
METHODS: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial.
RESULTS: Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels.
CONCLUSIONS: BCG responsiveness does not affect protection against atopy.
METHODS: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial.
RESULTS: Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels.
CONCLUSIONS: BCG responsiveness does not affect protection against atopy.