American journal of respiratory and critical care medicine · 2021
Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Burney Peter, Patel Jaymini, Minelli Cosetta, Gnatiuc Louisa, Amaral André F S, Kocabaş Ali, Cherkaski Hamid Hacene, Gulsvik Amund, Nielsen Rune, Bateman Eric, Jithoo Anamika, Mortimer Kevin, Sooronbaev Talant M, Lawin Hervé, Nejjari Chakib, Elbiaze Mohammed, El Rhazi Karima, Zheng Jin-Ping, Ran Pixin, Welte Tobias, Obaseki Daniel, Erhabor Gregory, Elsony Asma, Osman Nada Bakri, Ahmed Rana, Nizankowska-Mogilnicka Ewa, Mejza Filip, Mannino David M, Bárbara Cristina, Wouters Emiel F M, Idolor Luisito F, Loh Li-Cher, Rashid Abdul, Juvekar Sanjay, Gislason Thorarinn, Al Ghobain Mohamed, Studnicka Michael, Harrabi Imed, Denguezli Meriam, Koul Parvaiz A, Jenkins Christine, Marks Guy, Jõgi Rain, Hafizi Hasan, Janson Christer, Tan Wan C, Aquart-Stewart Althea, Mbatchou Bertrand, Nafees Asaad Ahmed, Gunasekera Kirthi, Seemungal Terry, Anand Mahesh Padukudru, Enright Paul, Vollmer William M, Blangiardo Marta, Elfadaly Fadlalla G, Buist A Sonia, BOLD Collaborative Research Group
Аннотация
Rationale: The Global Burden of Disease program identified smoking and ambient and household air pollution as the main drivers of death and disability from chronic obstructive pulmonary disease (COPD). Objectives: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged ≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a postbronchodilator FEV1-to-FVC ratio less than the lower limit of normal, and the relative risks associated with different risk factors. Local relative risks were estimated using a Bayesian hierarchical model borrowing information from across sites. From these relative risks and the prevalence of risk factors, we estimated local population attributable risks. Measurements and Main Results: The mean prevalence of CAO was 11.2% in men and 8.6% in women. The mean population attributable risk for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index, and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: Although smoking remains the most important risk factor for CAO, in some areas, poor education, low body mass index, and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.