Emerging infectious diseases · 2024
One Health Investigation into Mpox and Pets, United States.
СтатьяНазвание и аннотация: Перевод в очереди
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Morgan Clint N, Wendling Natalie M, Baird Nicolle, Kling Chantal, Lopez Leah, Navarra Terese, Fischer Gracie, Wynn Nhien, Ayuk-Takor Leslie, Darby Brandy, Murphy Julia, Wofford Rachel, Roth Emma, Holzbauer Stacy, Griffith Jayne, Ruprecht Ali, Harris Charlalynn, Gallardo-Romero Nadia, Doty Jeffrey B
Аннотация
Monkeypox virus (MPXV) is zoonotic and capable of infecting many mammal species. However, whether common companion animals are susceptible to MPXV infection is unclear. During July 2022-March 2023, we collected animal and environmental swab samples within homes of confirmed human mpox case-patients and tested for MPXV and human DNA by PCR. We also used ELISA for orthopoxvirus antibody detection. Overall, 12% (22/191) of animal and 25% (14/56) of environmental swab samples from 4 households, including samples from 4 dogs and 1 cat, were positive for MPXV DNA, but we did not detect viable MPXV or orthopoxvirus antibodies. Among MPXV PCR-positive swab samples, 82% from animals and 93% from environment amplified human DNA with a statistically significant correlation in observed cycle threshold values. Our findings demonstrate likely DNA contamination from the human mpox cases. Despite the high likelihood for exposure, we found no indications that companion animals were infected with MPXV.