Nature communications · 2016
T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Клиническое исследованиеСтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Fletcher Helen A, Snowden Margaret A, Landry Bernard, Rida Wasima, Satti Iman, Harris Stephanie A, Matsumiya Magali, Tanner Rachel, O'Shea Matthew K, Dheenadhayalan Veerabadran, Bogardus Leah, Stockdale Lisa, Marsay Leanne, Chomka Agnieszka, Harrington-Kandt Rachel, Manjaly-Thomas Zita-Rose, Naranbhai Vivek, Stylianou Elena, Darboe Fatoumatta, Penn-Nicholson Adam, Nemes Elisa, Hatherill Mark, Hussey Gregory, Mahomed Hassan, Tameris Michele, McClain J Bruce, Evans Thomas G, Hanekom Willem A, Scriba Thomas J, McShane Helen
Аннотация
Vaccines to protect against tuberculosis (TB) are urgently needed. We performed a case-control analysis to identify immune correlates of TB disease risk in Bacille Calmette-Guerin (BCG) immunized infants from the MVA85A efficacy trial. Among 53 TB case infants and 205 matched controls, the frequency of activated HLA-DR(+) CD4(+) T cells associates with increased TB disease risk (OR=1.828, 95% CI=1.25-2.68, P=0.002, FDR=0.04, conditional logistic regression). In an independent study of Mycobacterium tuberculosis-infected adolescents, activated HLA-DR(+) CD4(+) T cells also associate with increased TB disease risk (OR=1.387, 95% CI=1.068-1.801, P=0.014, conditional logistic regression). In infants, BCG-specific T cells secreting IFN-γ associate with reduced risk of TB (OR=0.502, 95% CI=0.29-0.86, P=0.013, FDR=0.14). The causes and impact of T-cell activation on disease risk should be considered when designing and testing TB vaccine candidates for these populations.
Предметные рубрики MeSH
AdolescentAntibody FormationBCG VaccineCD4-Positive T-LymphocytesCase-Control StudiesCohort StudiesHLA-DR AntigensHumansImmunityImmunoglobulin GInfantLogistic ModelsLymphocyte ActivationMycobacterium tuberculosisPlacebosRisk FactorsTime FactorsTuberculosisTuberculosis VaccinesVaccinationVaccines, DNA