Clinical profile and outcome of clinical BCG disease in infants.

OBJECTIVE

To describe the clinical profile, immunological status and outcome of BCG disease in infants.

METHODS

All infants with a diagnosis of BCG disease in a period of 17 months were followed up.

RESULTS

Among 25 infants with BCG disease; 19 had local/regional involvement and 6 had suspected or confirmed distant/disseminated disease, Mean (range) age of presentation was 3.6 (1.5-9) months. Two of 6 infants with disseminated disease required second-line anti-tubercular treatment. One infant with confirmed disseminated disease had INFg R1 receptor deficiency. There was no mortality.

CONCLUSION

Most infants with BCG- related disease have local or regional disease.