Future oncology (London, England) · 2015
Bleomycin pulmonary toxicity in adult Saudi patients with Hodgkin's lymphoma.
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Al-Jizani Wafa'a A, Al-Mansour Mubarak M, Al-Fayea Turki M, Shafi Ruaa U, Kazkaz Ghieth A, Bayer Ali M, Al-Foheidi Meteb E, Ibrahim Ezzeldin M
Аннотация
BACKGROUND: Bleomycin pulmonary toxicity (BPT) has been described in Hodgkin's lymphoma (HL) patients treated with bleomycin-containing chemotherapy regimens.
METHODOLOGY: We reviewed the records of 164 consecutive HL patients.
RESULTS: BPT was observed in 24 of 164 patients (15%). Older age and history of concomitant lung disease were significantly associated with approximately threefold (odds ratio: 3.38; 95% CI: 1.25-9.13; p = 0.02) and sevenfold (odds ratio: 7.19; 95% CI: 2.64-19.54; p < 0.0001) increase in BPT risk, respectively. The actuarial 5-year progression-free and overall survival for BPT and non-BPT groups, were not significantly different.
CONCLUSION: In Saudi Arabian HL patients, the risk of BPT and its effect on survival outcome were comparable to that reported from developed countries.
METHODOLOGY: We reviewed the records of 164 consecutive HL patients.
RESULTS: BPT was observed in 24 of 164 patients (15%). Older age and history of concomitant lung disease were significantly associated with approximately threefold (odds ratio: 3.38; 95% CI: 1.25-9.13; p = 0.02) and sevenfold (odds ratio: 7.19; 95% CI: 2.64-19.54; p < 0.0001) increase in BPT risk, respectively. The actuarial 5-year progression-free and overall survival for BPT and non-BPT groups, were not significantly different.
CONCLUSION: In Saudi Arabian HL patients, the risk of BPT and its effect on survival outcome were comparable to that reported from developed countries.