Emerging infectious diseases · 2013
Methicillin-resistant Staphylococcus aureus colonization of the groin and risk for clinical infection among HIV-infected adults.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Peters Philip J, Brooks John T, McAllister Sigrid K, Limbago Brandi, Lowery H Ken, Fosheim Gregory, Guest Jodie L, Gorwitz Rachel J, Bethea Monique, Hageman Jeffrey, Mindley Rondeen, McDougal Linda K, Rimland David
Аннотация
Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007-2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at enrollment and after 6 and 12 months. MRSA colonization was detected in 13%-15% of HIV-infected participants (n=600, 98% male) at baseline, 6 months, and 12 months. MRSA colonization was detected in the nares only (41%), groin only (21%), and at both sites (38%). Over a median of 2.1 years of follow-up, 29 MRSA clinical infections occurred in 25 participants. In multivariate analysis, MRSA clinical infection was significantly associated with MRSA colonization of the groin (adjusted risk ratio 4.8) and a history of MRSA infection (adjusted risk ratio 3.1). MRSA prevention strategies that can effectively prevent or eliminate groin colonization are likely necessary to reduce clinical infections in this population.