Clinical biochemistry · 2007
Use of an interferon-gamma based assay to assess bladder cancer patients treated with intravesical BCG and exposed to tuberculosis.
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Silverman M S, Reynolds D, Kavsak P A, Garay J, Daly A, Davis I
Аннотация
OBJECTIVE: Compare the QuantiFERON-TB Gold In-Tube (QFT) assay and the tuberculin skin test (TST) in bladder cancer patients receiving high dose BCG therapy (BCG patients).
DESIGN AND METHODS: BCG patients and healthy visitors, both exposed to tuberculosis, were screened with a TST and QFT.
RESULTS: QFT-TST correlation was excellent in visitors, but poor in BCG patients. BCG therapy predicted a positive TST (p<0.001) but not a positive QFT (p=0.35).
DISCUSSION: The management of BCG patients was impacted, by measuring the QFT.
DESIGN AND METHODS: BCG patients and healthy visitors, both exposed to tuberculosis, were screened with a TST and QFT.
RESULTS: QFT-TST correlation was excellent in visitors, but poor in BCG patients. BCG therapy predicted a positive TST (p<0.001) but not a positive QFT (p=0.35).
DISCUSSION: The management of BCG patients was impacted, by measuring the QFT.