Actas urologicas espanolas · 2002
[Intraprostatic BCG vaccine in patients with prostatic cancer. Expression of interferon gamma and interleukin 4 (a preliminary study)].
Сравнительное исследованиеАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Rivera P, Inostroza J, Treulén F
Аннотация
UNLABELLED: The BCG treatment in the superficial bladder cancer is utilized since 1976. There are some animal experiences with BCG intraprostatic in dogs with prostatic cancer.
GOAL: determine if insitu BCG vaccine increase the prostatic immunity in patients with prostatic cancer.
MATERIAL AND METHOD: Three patients with D stage prostatic cancer where injected with 0.3-0.5 mg of BCG vaccine in the prostate. An histological picture where made in the some place before and after the injection. A RT-PCR study was made for gamma Interferon and Interleukin-4.
RESULTS: In two patients we observed gamma interferon expression (67%) respect the control, this produce an increase of the cytotoxic T lymphocytes, natural killer cells and macrophagos, that have antitumoral action. One patient increased the interleukin-4 that means production of T helper lymphocytes and B lymphocytes. There wasn't complications.
CONCLUSIONS: The BCG vaccine injected in prostatic tissue of patients with prostatic cancer, produces an increase of cytotoxic T lymphocytes and natural killer cells, with antitumoral action.
GOAL: determine if insitu BCG vaccine increase the prostatic immunity in patients with prostatic cancer.
MATERIAL AND METHOD: Three patients with D stage prostatic cancer where injected with 0.3-0.5 mg of BCG vaccine in the prostate. An histological picture where made in the some place before and after the injection. A RT-PCR study was made for gamma Interferon and Interleukin-4.
RESULTS: In two patients we observed gamma interferon expression (67%) respect the control, this produce an increase of the cytotoxic T lymphocytes, natural killer cells and macrophagos, that have antitumoral action. One patient increased the interleukin-4 that means production of T helper lymphocytes and B lymphocytes. There wasn't complications.
CONCLUSIONS: The BCG vaccine injected in prostatic tissue of patients with prostatic cancer, produces an increase of cytotoxic T lymphocytes and natural killer cells, with antitumoral action.