[Repeated bladder metastases from renal cell carcinoma. Report of a case with particular attention to the use of immunomodulators].

The case of repeated metastases of the bladder from renal cell carcinoma in a 59 year old male patient is presented. Two years after nephrectomy the ureteral stump and the bladder were interested by two different metastases. Afterwards, other nine metastases developed into the bladder during the following 12 months. Biopsy with coagulation were performed in any case. Bladder metastases ranged between 2 and 4 mm. No other metastasis was discovered by MRI and skeletal scintigraphy. Thirteen months after the first bladder metastasis, intracavitary Bacillus Calmette-Guerin was used. No report was found in the literature about BCG in the treatment of superficial bladder metastases from renal cell carcinoma. However 15 months from beginning of BCG treatment no metastasis developed from the bladder that now is disease-free after a follow-up of 19 months.