Hypothesis-determinant factors in the manifestations of atopic disease.

It is postulated that both the initiation and the perpetuation of atopic disease occur as a result of a complex interaction of a genetically determined IgE response, increased permeability of the gastrointestinal and respiratory tracts, and an inherent metabolic instability that may be either localized or generalized. These three factors vary as a function of age and serve to explain the complicated natural history of allergic manifestations in atopic persons.