Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2026
Effectiveness of stepwise hepatitis B revaccination according to vaccination history in healthcare students: a retrospective observational study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sato Hiroe, Nozawa Yukiko, Tajiri Misuzu, Yutani Motoki, Takeshi Kuroda
Аннотация
INTRODUCTION: Hepatitis B vaccination and confirmation of adequate immune response are essential for healthcare students at risk of occupational exposure; however, the optimal number of additional doses for individuals who remain anti-hepatitis B surface antigen antibody (anti-HBs)-negative after primary vaccination remains unclear. We conducted a retrospective observational study of medical and dental students enrolled between 2019 and 2023.
METHODS: Participants included 1624 students who received a primary three-dose hepatitis B vaccination series after enrollment and 70 students with a history of hepatitis B vaccination before enrollment who were anti-HBs-negative at enrollment. Students who were anti-HBs-negative after the primary series or at enrollment received one additional dose, followed by two further doses if they remained anti-HBs-negative.
RESULTS: Among students who received primary vaccination after enrollment, seroconversion was achieved in 98.1% after the primary series. Of those who remained anti-HBs-negative, 71.0% achieved seroconversion after one additional dose, and 77.8% of the remaining students after two further doses. In contrast, students with pre-enrollment vaccination showed a higher seroconversion rate after one additional dose (88.6%). Anti-HBs antibody titers after the additional dose were significantly higher in students with pre-enrollment vaccination than in those with post-enrollment primary vaccination.
CONCLUSIONS: The effectiveness of stepwise hepatitis B revaccination differs according to vaccination history. A single additional dose may be appropriate for students with prior vaccination, whereas planned multiple-dose revaccination may be more effective for those who remain anti-HBs-negative after primary vaccination initiated after enrollment.
METHODS: Participants included 1624 students who received a primary three-dose hepatitis B vaccination series after enrollment and 70 students with a history of hepatitis B vaccination before enrollment who were anti-HBs-negative at enrollment. Students who were anti-HBs-negative after the primary series or at enrollment received one additional dose, followed by two further doses if they remained anti-HBs-negative.
RESULTS: Among students who received primary vaccination after enrollment, seroconversion was achieved in 98.1% after the primary series. Of those who remained anti-HBs-negative, 71.0% achieved seroconversion after one additional dose, and 77.8% of the remaining students after two further doses. In contrast, students with pre-enrollment vaccination showed a higher seroconversion rate after one additional dose (88.6%). Anti-HBs antibody titers after the additional dose were significantly higher in students with pre-enrollment vaccination than in those with post-enrollment primary vaccination.
CONCLUSIONS: The effectiveness of stepwise hepatitis B revaccination differs according to vaccination history. A single additional dose may be appropriate for students with prior vaccination, whereas planned multiple-dose revaccination may be more effective for those who remain anti-HBs-negative after primary vaccination initiated after enrollment.