Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA · 2004
Dynamics of intestinal flora after oral vaccination with inactivated whole-cell/recombinant B subunit O139 cholera vaccine.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wu Hui-xu, Chen Qing, Li Jian-dong, Huang Xiu-fen
Аннотация
OBJECTIVE: To investigate the change of intestinal flora in subjects receiving oral vaccination with inactivated whole-cell/recombinant B subunit (WC/rBS) O139 cholera vaccine made in China.
METHODS: The fecal smears of 5 groups of subjects receiving the vaccine were collected before and 2 and 3 months after the vaccination to examine the distribution of the intestinal flora.
RESULTS: In the 458 specimens examined, the total amount of bacteria and percentages of G+b, G+c and G-c were decreased whereas the amount of G-b significantly increased after vaccination. Compared with the placebo control group, the vaccinated groups exhibited significant changes in G+b and G-c, which also varied significantly between the group receiving 3 doses of WC/rBS vaccine and the other vaccinated groups. The vaccination produced distinct changes in the percentage of the intestinal flora at different time points, showing the most obvious effect on G-b. Oral vaccination was shown to affect the percentage of the intestinal flora very likely through its effect on the amount of G-b. The percentages of G+b, G-b and G-c varied significantly between male and female subjects after vaccination.
CONCLUSION: Oral vaccination with WC/rBS affects the intestinal flora in human, and the mechanism as well as the implications needs to be further explored.
METHODS: The fecal smears of 5 groups of subjects receiving the vaccine were collected before and 2 and 3 months after the vaccination to examine the distribution of the intestinal flora.
RESULTS: In the 458 specimens examined, the total amount of bacteria and percentages of G+b, G+c and G-c were decreased whereas the amount of G-b significantly increased after vaccination. Compared with the placebo control group, the vaccinated groups exhibited significant changes in G+b and G-c, which also varied significantly between the group receiving 3 doses of WC/rBS vaccine and the other vaccinated groups. The vaccination produced distinct changes in the percentage of the intestinal flora at different time points, showing the most obvious effect on G-b. Oral vaccination was shown to affect the percentage of the intestinal flora very likely through its effect on the amount of G-b. The percentages of G+b, G-b and G-c varied significantly between male and female subjects after vaccination.
CONCLUSION: Oral vaccination with WC/rBS affects the intestinal flora in human, and the mechanism as well as the implications needs to be further explored.