Clinical nutrition ESPEN · 2026
Impact of the global leadership initiative on malnutrition criteria on the quality of life of patients with ulcerative colitis.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Masuda Naoya, Miwa Takao, Nishimura Kayoko, Miwa Yoshiyuki, Kojima Kentaro, Onishi Sachiyo, Takada Jun, Kubota Masaya, Ibuka Takashi, Shimizu Masahito
Аннотация
BACKGROUND & AIMS: Limited evidence is available regarding the Global Leadership Initiative on Malnutrition (GLIM), a standardized diagnostic criterion for malnutrition, in outpatients with ulcerative colitis (UC). This study aimed to investigate the prevalence and determinants of GLIM-defined malnutrition and their impact on the quality of life (QOL) in this population.
METHODS: This multicenter, cross-sectional study included outpatients with UC from two institutes in Gifu, Japan. Malnutrition was diagnosed using the GLIM criteria and Malnutrition Universal Screening Tool for initial screening. QOL was assessed using the Japanese version of the Inflammatory Bowel Disease questionnaire (J-IBDQ). The malnutrition determinants were evaluated using a multivariate logistic regression model.
RESULTS: Of the 240 outpatients, the median age was 53 years and 41.7 % were female. Extensive colitis was observed in 45.0 % of the patients, and 29.6 % experienced advanced therapy. With nutritional assessment, 28.3 % were at risk of malnutrition and 10.4 % were diagnosed with GLIM-defined malnutrition. Multivariable analysis identified female sex (odds ratio [OR] 3.24, 95 % confidence interval [CI] 1.35-8.28), extensive colitis (OR 2.75, 95 % CI 1.09-7.45), and a history of advanced therapy (OR 2.71, 95 % CI 1.11-6.67) as independent factors for malnutrition. Compared with those of well-nourished patients, those with malnutrition had significantly lower scores in all four domains and total J-IBDQ score.
CONCLUSIONS: Malnutrition, as defined by the GLIM criteria, was observed in 10.4 % of the outpatients with UC; female sex, extensive colitis, and advanced therapy were robust determinants. Furthermore, patients with malnutrition had a significantly poorer QOL than that of those who were well-nourished.
CLINICAL TRIAL REGISTRATION: N/A.
METHODS: This multicenter, cross-sectional study included outpatients with UC from two institutes in Gifu, Japan. Malnutrition was diagnosed using the GLIM criteria and Malnutrition Universal Screening Tool for initial screening. QOL was assessed using the Japanese version of the Inflammatory Bowel Disease questionnaire (J-IBDQ). The malnutrition determinants were evaluated using a multivariate logistic regression model.
RESULTS: Of the 240 outpatients, the median age was 53 years and 41.7 % were female. Extensive colitis was observed in 45.0 % of the patients, and 29.6 % experienced advanced therapy. With nutritional assessment, 28.3 % were at risk of malnutrition and 10.4 % were diagnosed with GLIM-defined malnutrition. Multivariable analysis identified female sex (odds ratio [OR] 3.24, 95 % confidence interval [CI] 1.35-8.28), extensive colitis (OR 2.75, 95 % CI 1.09-7.45), and a history of advanced therapy (OR 2.71, 95 % CI 1.11-6.67) as independent factors for malnutrition. Compared with those of well-nourished patients, those with malnutrition had significantly lower scores in all four domains and total J-IBDQ score.
CONCLUSIONS: Malnutrition, as defined by the GLIM criteria, was observed in 10.4 % of the outpatients with UC; female sex, extensive colitis, and advanced therapy were robust determinants. Furthermore, patients with malnutrition had a significantly poorer QOL than that of those who were well-nourished.
CLINICAL TRIAL REGISTRATION: N/A.